Midtown was the older, less dense district located in the central part of the Monkeytown. Midtown consisted of mostly residential apartments and commercial development, as well as Quackmire Park. The district was bounded by South Main Street and Yonkers Road to the north, Broadway to the southwest, and Capuchin Boulevard to the east. Highway 101 ran through the center of Midtown. The Monkeytown Police Station was located in Midtown.
- Main article: List of Monkeytown residents